Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683880 | 0.79 | AGTR1 (0.56) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL12894934 | 0.78 | AGTR1 (0.40) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL682681 | 0.77 | AGTR1 (0.46) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL684172 | 0.76 | AGTR1 (0.44) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL8804932 | 0.71 | AGTR1 (0.49) | AGTR1TBXA2RAGTR2PDE3A | |
| Tasosartan SCHEMBL49626 | 0.67 | AGTR1 (0.71) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL7429405 | 0.66 | AGTR1 (0.61) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL683802 | 0.66 | AGTR1 (0.50) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL8803578 | 0.65 | AGTR1 (0.55) | AGTR1TBXA2RAGTR2PDE3A | |
| SCHEMBL683800 | 0.65 | AGTR1 (0.55) | AGTR1TBXA2RAGTR2PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498776-A | Substituted pyrrolopyrimidines and pyridopyrimidines useful as angiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-03-12 | — | — | US | disclosed |