Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CASP5 | P51878 | 2/20 | 0.34 |
| ▸ | CASP4 | P49662 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8964998 | 0.85 | PIM2 (0.47) | CHRNB2CHRNA4PIM2PRKCAPRKCQ | |
| SCHEMBL9008503 | 0.83 | PRKCQ (0.47) | PIM2SMN1; SMN2ADRB1PRKD1PRKD2 | |
| SCHEMBL13857168 | 0.83 | PRKCA (0.39) | PIM2SMN1; SMN2ADRB1PRKD1PRKD2 | |
| SCHEMBL8964036 | 0.83 | PRKCA (0.52) | CHRNB2CHRNA4PIM2PRKCAPRKCQ | |
| SCHEMBL8964785 | 0.77 | PRKCA (0.52) | CHRNB2CHRNA4PIM2ADRB1PRKCA | |
| SCHEMBL8964982 | 0.72 | PRKCA (0.49) | CHRNB2CHRNA4SMN1; SMN2ADRB1PRKD1 | |
| SCHEMBL8965021 | 0.72 | PIM2 (0.52) | CHRNB2CHRNA4PIM2PRKCAPRKCQ | |
| SCHEMBL8965888 | 0.72 | PRKCA (0.51) | CHRNB2CHRNA4PIM2PRKCAPRKCQ | |
| SCHEMBL13857133 | 0.70 | PIM2 (0.44) | CHRNB2CHRNA4PIM2PRKCAPRKCQ | |
| SCHEMBL9011731 | 0.70 | PRKCQ (0.51) | CHRNB2CHRNA4PIM2PRKCAPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140221334-A1 | KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-07 | — | — | US | disclosed |
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090124602-A1 | KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221334-A1 | KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | CHRNB2 4583/4885CHRNA4 4655/4885PIM2 415/4885 |
| US-20090124602-A1 | KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | CHRNB2 4583/4885CHRNA4 4655/4885PIM2 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.