Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369314 | 0.92 | KDR (0.44) | KDRPIK3CAKDM4EMETCSNK1D | |
| SCHEMBL8965609 | 0.91 | KDR (0.46) | KDRPIK3CG | |
| SCHEMBL8965590 | 0.88 | PIK3CA (0.45) | KDRPIK3CAMETCSNK1DPIK3CD | |
| SCHEMBL8965977 | 0.86 | PIK3CA (0.44) | KDRPIK3CAKDM4EMETCSNK1D | |
| SCHEMBL8965591 | 0.84 | PIK3CA (0.43) | KDRPIK3CAKDM4EMETCSNK1D | |
| SCHEMBL8965899 | 0.83 | KDR (0.40) | KDRPIK3CAKDM4EMETCSNK1D | |
| SCHEMBL8965850 | 0.83 | KDR (0.45) | KDRPIK3CACSNK1DAURKAPDGFRB | |
| Hydrochloric Acid SCHEMBL8965648 | 0.83 | KDR (0.45) | KDRPIK3CACSNK1DAURKAPDGFRB | |
| SCHEMBL8965662 | 0.82 | ADORA3 (0.45) | KDRCSNK1D | |
| SCHEMBL9373805 | 0.82 | KDR (0.50) | KDRPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538970-A | Treatment of cancer with imidazo-1,2-pyridazin compounds | GLAXO WELLCOME INC. (US) | 1996-07-23 | — | — | US | disclosed |
| US-5447956-A | Anticarcinogenic agents | BURROUGHS WELLCOME CO. (US) | 1995-09-05 | — | — | US | disclosed |
| US-5380759-A | Methyl N-[6-(3,4,5-trimethoxybenzloxy)imidazo[1,2-b]pyridazin-2-zyl]carbamate used to treat leukemia | BURROUGHS WELLCOME CO. (US) | 1995-01-10 | — | — | US | disclosed |
| US-5091531-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0305093-A1 | Imidazo(1,2-b)pyridazine derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-03-01 | — | — | EP | disclosed |