Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | KLK3 | P07288 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966049 | 0.87 | ESR1 (0.41) | TP53MAPTESR1ESR2AR | |
| SCHEMBL17765439 | 0.81 | HPGD (0.48) | MEN1KMT2ANPC1GAATP53 | |
| SCHEMBL17777815 | 0.81 | ESR1 (0.39) | MEN1KMT2AGAAPOLBMAPT | |
| SCHEMBL7520996 | 0.78 | KMT2A (0.61) | MEN1KMT2ANPC1GAAALDH1A1 | |
| Benzene SCHEMBL28134446 | 0.76 | MEN1 (0.59) | MEN1KMT2ANPC1GAATP53 | |
| SCHEMBL28081301 | 0.76 | KMT2A (0.44) | MEN1KMT2ANPC1GAAALDH1A1 | |
| SCHEMBL27880163 | 0.75 | KMT2A (0.46) | MEN1KMT2ANPC1GAATP53 | |
| SCHEMBL27967593 | 0.74 | KMT2A (0.45) | MEN1KMT2ANPC1GAAALDH1A1 | |
| SCHEMBL10685337 | 0.74 | KDM1A (0.42) | NPC1MAPTESR1ESR2ALDH1A1 | |
| SCHEMBL18926276 | 0.73 | NPC1 (0.55) | MEN1KMT2ANPC1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524742-B1 | Benzo(a)fluorene compounds | LILLY CO ELI (US) | 1996-02-28 | — | — | EP | disclosed |
| EP-0524742-A2 | Benzo(a)fluorene compounds | ELI LILLY AND COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |
| US-5147880-A | Estrogenic and antiestrogenic activity | ELI LILLY AND COMPANY (US) | 1992-09-15 | — | — | US | disclosed |