Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 10/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL933699 | 0.77 | BCAT2 (0.55) | BCAT2ALDH1A1RAB9A | |
| SCHEMBL8965864 | 0.76 | CNR1 (0.47) | BCAT2FFAR1RAB9A | |
| SCHEMBL8965974 | 0.76 | IDO1 (0.51) | BCAT2ALDH1A1 | |
| SCHEMBL8966253 | 0.75 | BCAT2 (0.41) | BCAT2ALDH1A1HSD17B10TP53 | |
| SCHEMBL28425403 | 0.73 | BCAT2 (0.59) | BCAT2ALDH1A1HSD17B10TP53MAPK1 | |
| SCHEMBL27718811 | 0.71 | FFAR1 (0.62) | DPP4FFAR1FFAR4ALDH1A1PTGER1 | |
| SCHEMBL8965572 | 0.70 | SYK (0.47) | BCAT2ALDH1A1 | |
| SCHEMBL8966305 | 0.70 | ABCB1 (0.49) | RAB9A | |
| SCHEMBL1521309 | 0.69 | DPP4 (0.59) | DPP4TACR1 | |
| SCHEMBL336977 | 0.68 | TACR1 (0.62) | DPP4CD274FFAR1FFAR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538970-A | Treatment of cancer with imidazo-1,2-pyridazin compounds | GLAXO WELLCOME INC. (US) | 1996-07-23 | — | — | US | disclosed |
| US-5447956-A | Anticarcinogenic agents | BURROUGHS WELLCOME CO. (US) | 1995-09-05 | — | — | US | disclosed |
| US-5380759-A | Methyl N-[6-(3,4,5-trimethoxybenzloxy)imidazo[1,2-b]pyridazin-2-zyl]carbamate used to treat leukemia | BURROUGHS WELLCOME CO. (US) | 1995-01-10 | — | — | US | disclosed |
| US-5371219-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1994-12-06 | — | — | US | disclosed |
| CN-1085901-A | Preparation contains the method for the antineoplastic pharmaceutical compositions of Imidazopyridazine derivative | WELLCOME FOUND (GB) | 1994-04-27 | — | — | CN | disclosed |
| EP-0305093-B1 | Imidazo(1,2-b)pyridazine derivatives | WELLCOME FOUND (GB) | 1994-04-06 | — | — | EP | disclosed |
| US-5091531-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1992-02-25 | — | — | US | disclosed |
| CN-1031532-A | HETEROCYCLIC COMPOUNDS | WELLCOME FOUND (GB) | 1989-03-08 | — | — | CN | disclosed |
| EP-0305093-A1 | Imidazo(1,2-b)pyridazine derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-03-01 | — | — | EP | disclosed |