Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 13/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9157347 | 0.91 | PDE10A (0.41) | KDRCSNK1DRIPK1PIK3CAPDE10A | |
| SCHEMBL8965615 | 0.88 | RIPK1 (0.41) | KDRCSNK1DRIPK1PIK3CAPDE10A | |
| SCHEMBL8965537 | 0.86 | RIPK1 (0.43) | KDRCSNK1DRIPK1PIK3CA | |
| SCHEMBL8965637 | 0.85 | ATM (0.44) | KDRCSNK1DRIPK1PIK3CAPDE10A | |
| SCHEMBL8966250 | 0.84 | CSNK1D (0.39) | KDRCSNK1DRIPK1PIK3CAPDE10A | |
| SCHEMBL9280653 | 0.84 | CSNK1D (0.44) | CSNK1DRIPK1PIK3CAPDE10A | |
| SCHEMBL8966017 | 0.81 | KDR (0.41) | KDRCSNK1DRIPK1PIK3CA | |
| SCHEMBL8965870 | 0.81 | PDE10A (0.42) | KDRCSNK1DPIK3CAPDE10A | |
| SCHEMBL8965899 | 0.79 | KDR (0.40) | KDRCSNK1DRIPK1PIK3CA | |
| SCHEMBL8965955 | 0.79 | KDR (0.43) | KDRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538970-A | Treatment of cancer with imidazo-1,2-pyridazin compounds | GLAXO WELLCOME INC. (US) | 1996-07-23 | — | — | US | disclosed |
| US-5447956-A | Anticarcinogenic agents | BURROUGHS WELLCOME CO. (US) | 1995-09-05 | — | — | US | disclosed |
| US-5371219-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1994-12-06 | — | — | US | disclosed |