SCHEMBL8967091

SCHEMBL8967091

O=C(c1ccc(Cl)cc1)c1ccc(Sc2ccc(C(=O)c3ccc(Cl)cc3)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 1/20 0.61
MAPK1 P28482 1/20 0.61
HPGD P15428 4/20 0.53
CES2 O00748 1/20 0.52
CES1 P23141 1/20 0.52
LMNA P02545 2/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
ALOX15 P16050 1/20 0.50
TSHR P16473 1/20 0.50
CTRC Q99895 1/20 0.50
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
CNR1 P21554 1/20 0.47
CNR2 P34972 1/20 0.47
NR4A1 P22736 1/20 0.47
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
ELANE P08246 1/20 0.46
ALDH1A1 P00352 2/20 0.45
CYP2C9 P11712 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9475945 1.00 SRD5A2 (0.61) SRD5A2MAPK1HPGDCES2CES1
SCHEMBL8771928 0.92 SRD5A2 (0.59) SRD5A2MAPK1HPGDCES2CES1
SCHEMBL8967798 0.92 MAPK1 (0.77) SRD5A2MAPK1HPGDCES2CES1
SCHEMBL10697158 0.85 SRD5A2 (0.80) SRD5A2MAPK1HPGDCES2CES1
SCHEMBL9065412 0.85 SRD5A2 (0.80) SRD5A2MAPK1HPGDCES2CES1
SCHEMBL51827 0.85 SRD5A2 (0.80) SRD5A2MAPK1HPGDCES2CES1
SCHEMBL1681512 0.85 SRD5A2 (0.80) SRD5A2MAPK1HPGDCES2CES1
SCHEMBL9418093 0.84 TSHR (0.74) SRD5A2HPGDCES2CES1LMNA
SCHEMBL10991208 0.84 HPGD (0.50) SRD5A2MAPK1HPGDCES2CES1
SCHEMBL9418097 0.84 TSHR (0.74) SRD5A2HPGDCES2CES1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0306051-B1 Process for production of aromatic polyethers MITSUBISHI GAS CHEMICAL CO (JP) 1996-03-06 EP claimed
US-4952665-A Process for production of aromatic polyethers with alkali metal carbonate/bicarbonate/fluoride cocatalyst MITSUBISHI GAS CHEMICAL COMPANY, LTD. (JP) 1990-08-28 US claimed
EP-0306051-A1 Process for production of aromatic polyethers MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1989-03-08 EP claimed
US-5266674-A Copolymers PHILLIPS PETROLEUM COMPANY (US) 1993-11-30 US disclosed
US-5264176-A Washing with calcium salt, heating to remove water, molding, stretching, setting; heat resistance, melt stability PHILLIPS PETROLEUM COMPANY (US) 1993-11-23 US disclosed
US-5239042-A Dibenzofuran polymer ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1993-08-24 US disclosed
US-5109102-A Reacting alkali metal sulfide and dihaloaromatic ketone in polar organic compound, polymerizing, dehydrating, adding more ketone, polymerizing; high molecular weight PHILLIPS PETROLEUM COMPANY (US) 1992-04-28 US disclosed
US-5089596-A From dihaloaromatic ketone, alkali metal sulfide, water, and polar organic compound PHILLIPS PETROLEUM COMPANY (US) 1992-02-18 US disclosed
US-5071944-A Dihalaromatic ketone and alkali metal sulfide, heating to dehy drate PHILLIPS PETROLEUM COMPANY (US) 1991-12-10 US disclosed
EP-0450635-A2 Process for preparing branched poly(arylene sulfide ketone) PHILLIPS PETROLEUM COMPANY (US) 1991-10-09 EP disclosed
US-5003033-A Engineering thermoplastics for films, molding materials and composites PHILLIPS PETROLEUM COMPANY (US) 1991-03-26 US disclosed
EP-0385299-A1 Production of aromatic sulfide/ketone Polymers PHILLIPS PETROLEUM COMPANY (US) 1990-09-05 EP disclosed
EP-0306884-A1 Production of aromatic sulfide/ketone polymers PHILLIPS PETROLEUM COMPANY (US) 1989-03-15 EP disclosed
US-4795799-A FROM DIHALOAROMATIC KETONE AND ALKALI METAL HYDROSULFIDE PHILLIPS PETROLEUM COMPANY (US) 1989-01-03 US disclosed
US-4567248-A Branched, high molecular weight, thermoplastic polyarylene ethers containing nitrile groups, and their preparation BASF AKTIENGESELLSCHAFT (DE) 1986-01-28 US disclosed
EP-0147708-A2 Polyaryl ethers containing branched, high molecular weight thermoplastic nitrile groups, and their preparation BASF Aktiengesellschaft (DE) 1985-07-10 EP disclosed
US-4324881-A FROM DIHALOBENZENE COMPOUND AND AMIDE-CONTAINING BISPHENOL, ALKALI METAL CARBONATE BASF AKTIENGESELLSCHAFT (DE) 1982-04-13 US disclosed
EP-0001768-B1 PROCESS FOR THE PRODUCTION OF POLYETHERS BASF Aktiengesellschaft (DE) 1981-06-17 EP disclosed
US-4200727-A Manufacture of polyethers from bisphenols and dihalides in the absence of solvent and in the presence of alkali metal carbonate BASF AKTIENGESELLSCHAFT (DE) 1980-04-29 US disclosed
US-4200728-A Manufacture of polyethers from bis-(4-hydroxyphenyl)-sulfone and bis-(4-chlorophenyl)-sulfone in N-methylpyrrolidone using an alkali metal carbonate as catalysts BASF AKTIENGESELLSCHAFT (DE) 1980-04-29 US disclosed