Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21787690 | 0.82 | KCNH2 (0.35) | KCNH2 | |
| SCHEMBL8966744 | 0.81 | GBA1 (0.37) | KCNH2 | |
| SCHEMBL8162761 | 0.81 | KCNH2 (0.31) | KCNH2 | |
| SCHEMBL12384574 | 0.77 | TRPA1 (0.31) | KCNH2 | |
| SCHEMBL20676098 | 0.77 | TRPA1 (0.31) | KCNH2 | |
| SCHEMBL19122839 | 0.77 | TRPA1 (0.31) | KCNH2 | |
| SCHEMBL18309924 | 0.77 | TRPA1 (0.31) | KCNH2 | |
| SCHEMBL18309925 | 0.77 | TRPA1 (0.31) | KCNH2 | |
| SCHEMBL17311156 | 0.74 | — | — | |
| SCHEMBL2095890 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468434-B1 | Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis | MERRELL DOW PHARMA (US) | 1996-02-28 | — | — | EP | disclosed |
| US-5348964-A | Anticholesterol agents or fungicides | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-09-20 | — | — | US | disclosed |
| EP-0468434-A1 | Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | disclosed |