Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967026 | 0.83 | ADORA2A (0.43) | NPC1RAB9ASMN1; SMN2L3MBTL1ADORA2A | |
| SCHEMBL8967950 | 0.83 | ADORA2A (0.40) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8967532 | 0.82 | PLOD2 (0.43) | NPC1RAB9ASMN1; SMN2EPHX2ADORA2A | |
| SCHEMBL8967819 | 0.80 | KMT2A (0.48) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8967967 | 0.79 | ADORA2A (0.40) | SMN1; SMN2MEN1KMT2AADORA2AADORA1 | |
| SCHEMBL8967717 | 0.79 | ADORA2A (0.40) | EPHX2ADORA2AADORA1MAPTALDH1A1 | |
| SCHEMBL8967508 | 0.79 | CYP11B1 (0.47) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8968052 | 0.77 | ADORA2A (0.38) | SMN1; SMN2MEN1KMT2AADORA2AADORA1 | |
| SCHEMBL8967604 | 0.77 | ADORA2A (0.38) | SMN1; SMN2MEN1KMT2AADORA2AADORA1 | |
| SCHEMBL8968084 | 0.77 | ADORA2A (0.38) | SMN1; SMN2MEN1KMT2AADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815866-B2 | Aminopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-26 | — | — | US | disclosed |
| US-20140221334-A1 | KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-07 | — | — | US | disclosed |
| US-20130137703-A1 | AMINOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-05-30 | — | — | US | disclosed |
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221334-A1 | KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | NPC1 1348/4885RAB9A 1636/4885SMN1; SMN2 1649/4885 |
| US-20130137703-A1 | AMINOPYRIDINE KINASE INHIBITORS | MAP3K5, MAP3K20, MAP4K5 | NPC1 3119/4885RAB9A 1974/4885SMN1; SMN2 1869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.