Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15438320 | 0.82 | TSHR (0.46) | TSHRGAAMGAMSIMGAM2 | |
| SCHEMBL17504766 | 0.80 | TSHR (0.46) | TSHRPPARDTDP1ALDH1A1MEN1 | |
| SCHEMBL15438312 | 0.78 | TSHR (0.43) | TSHRPPARDALDH1A1 | |
| SCHEMBL9617309 | 0.78 | TSHR (0.43) | TSHRGAAMGAMSIMGAM2 | |
| SCHEMBL10880520 | 0.78 | TSHR (0.43) | TSHRGAAMGAMSIMGAM2 | |
| SCHEMBL15438142 | 0.77 | TSHR (0.50) | TSHRGAAMGAMSIMGAM2 | |
| SCHEMBL15438833 | 0.76 | TSHR (0.44) | TSHRGAAMGAMSIMGAM2 | |
| SCHEMBL21805454 | 0.76 | DGKA (0.46) | TSHRSMN1; SMN2 | |
| SCHEMBL15438668 | 0.76 | TSHR (0.45) | TSHRGAAMGAMSIMGAM2 | |
| SCHEMBL16558619 | 0.76 | TSHR (0.40) | TSHRGAAMGAMSIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5523430-A | Protein farnesyl transferase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-04 | — | — | US | disclosed |