Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GGT1 | P19440 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL10779822 | 0.95 | ALDH1A1 (0.74) | ALDH1A1ALOX15AKR1C3KMT2ATDP1 | |
| Phthalic Acid SCHEMBL27681760 | 0.93 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KMT2ATDP1 | |
| Phthalic Acid SCHEMBL5888909 | 0.93 | ALDH1A1 (0.78) | ALDH1A1ALOX15AKR1C3KMT2AAPEX1 | |
| Phthalic Acid SCHEMBL30182240 | 0.93 | ALDH1A1 (0.78) | ALDH1A1ALOX15AKR1C3KMT2AAPEX1 | |
| Phthalic Acid SCHEMBL1532704 | 0.93 | ALDH1A1 (0.78) | ALDH1A1ALOX15AKR1C3KMT2AAPEX1 | |
| Phthalic Acid SCHEMBL3671128 | 0.93 | ALDH1A1 (0.78) | ALDH1A1ALOX15AKR1C3KMT2AAPEX1 | |
| Phthalic Acid SCHEMBL28283200 | 0.91 | ALDH1A1 (0.67) | ALDH1A1ALOX15AKR1C3KMT2ATDP1 | |
| Phthalic Acid SCHEMBL27901342 | 0.90 | ALDH1A1 (0.74) | ALDH1A1ALOX15AKR1C3KMT2AAPEX1 | |
| Phthalic Acid SCHEMBL27783718 | 0.90 | ALDH1A1 (0.74) | ALDH1A1ALOX15AKR1C3KMT2AAPEX1 | |
| Phthalic Acid SCHEMBL3671126 | 0.88 | ALDH1A1 (0.70) | ALDH1A1ALOX15AKR1C3KMT2AAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5525291-A | EXTRUDING MIXTURE OF METAL, CARBON OR CERAMIC PARTICLES, WITH BINDER AND SOLVENT, THROUGH ADJUSTABLE DIE WHICH CAN BE MOVED DURING EXTRUSION YIELDS HONEYCOMBS HAVING CONTROLLED CELL STRUCTURES | CORNING INCORPORATED (US) | 1996-06-11 | — | — | US | disclosed |