Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 15/20 | 0.54 |
| ▸ | PRKCA | P17252 | 2/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.47 |
| ▸ | SMO | Q99835 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1479331 | 0.90 | CKS1B (0.53) | PRKCQPRKCAPRKCDCKS1BSKP1 | |
| SCHEMBL9010401 | 0.90 | PRKCQ (0.53) | PRKCQPRKCAPRKCDHRH3CKS1B | |
| SCHEMBL8970237 | 0.86 | PRKCQ (0.58) | PRKCQPRKCAPRKCD | |
| SCHEMBL8969522 | 0.86 | PRKCQ (0.73) | PRKCQPRKCAPRKCD | |
| SCHEMBL16071357 | 0.83 | PRKCQ (0.53) | PRKCQPRKCAPRKCD | |
| SCHEMBL8970038 | 0.81 | PRKCQ (0.56) | PRKCQPRKCAPRKCD | |
| SCHEMBL13857182 | 0.81 | PRKCQ (0.45) | PRKCQPRKCAPRKCDSMOHRH3 | |
| SCHEMBL8969924 | 0.81 | CKS1B (0.51) | PRKCQPRKCAPRKCDCKS1BSKP1 | |
| SCHEMBL8185355 | 0.81 | PRKCQ (0.71) | PRKCQPRKCAPRKCD | |
| SCHEMBL11993695 | 0.81 | PRKCQ (0.52) | PRKCQPRKCAPRKCDHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |