Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Egtazic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.74 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | EYA2 | O00167 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Egtazic Acid SCHEMBL249025 | 0.98 | BLM (0.77) | BLMPMP22HSD17B10TDP1EYA2 | |
| Egtazic Acid SCHEMBL3631773 | 0.92 | BLM (0.87) | BLMPMP22HSD17B10TDP1EYA2 | |
| Egtazic Acid SCHEMBL4587716 | 0.92 | BLM (0.87) | BLMPMP22HSD17B10TDP1EYA2 | |
| Ethylene Glycol SCHEMBL5335726 | 0.90 | BLM (0.83) | BLMPMP22HSD17B10TDP1EYA2 | |
| Ethylene Glycol SCHEMBL6500129 | 0.90 | BLM (0.83) | BLMPMP22HSD17B10TDP1EYA2 | |
| Egtazic Acid SCHEMBL16652710 | 0.90 | BLM (0.65) | BLMPMP22HSD17B10TDP1EYA2 | |
| Egtazic Acid SCHEMBL20954039 | 0.89 | BLM (0.80) | BLMPMP22HSD17B10TDP1EYA2 | |
| Egtazic Acid SCHEMBL7693453 | 0.88 | BLM (0.87) | BLMPMP22HSD17B10TDP1EYA2 | |
| Egtazic Acid SCHEMBL920203 | 0.86 | BLM (1.00) | BLMPMP22HSD17B10TDP1EYA2 | |
| Egtazic Acid SCHEMBL22901 | 0.86 | BLM (1.00) | BLMPMP22HSD17B10TDP1EYA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044986-A2 | VISCOSIFIED FLUID LOSS CONTROL AGENT UTILIZING CHELATES | M-I L.L.C. (US) | 2012-04-05 | — | — | WO | disclosed |