Egtazic Acid

Egtazic Acid

SCHEMBL920203

O=C(O)CN(CCOCCOCCN(CC(=O)O)CC(=O)O)CC(=O)O.O=C(O)CN(CCOCCOCCN(CC(=O)O)CC(=O)O)CC(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BLM P54132 2/20 1.00
PMP22 Q01453 2/20 1.00
HSD17B10 Q99714 1/20 1.00
TDP1 Q9NUW8 2/20 0.62
EYA2 O00167 1/20 0.62
APP P05067 1/20 0.62
ACE P12821 1/20 0.62
KDM4E B2RXH2 1/20 0.59
LMNA P02545 1/20 0.59
CHRM2 P08172 1/20 0.59
ADRA2A P08913 1/20 0.59
ALOX15 P16050 1/20 0.59
TSHR P16473 1/20 0.59
DRD1 P21728 1/20 0.59
SLC6A2 P23975 1/20 0.59
SLC6A4 P31645 1/20 0.59
CYP2C19 P33261 1/20 0.59
ADRA1A P35348 1/20 0.59
DRD3 P35462 1/20 0.59
SLC6A3 Q01959 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11684972 1.00 BLM (1.00) BLMPMP22HSD17B10TDP1EYA2
Egtazic Acid SCHEMBL22901 1.00 BLM (1.00) BLMPMP22HSD17B10TDP1EYA2
Egtazic Acid SCHEMBL831877 0.98 BLM (0.95) BLMPMP22HSD17B10TDP1EYA2
Egtazic Acid SCHEMBL456632 0.98 BLM (0.95) BLMPMP22HSD17B10TDP1EYA2
Egtazic Acid SCHEMBL5067266 0.98 BLM (0.95) BLMPMP22HSD17B10TDP1EYA2
Egtazic Acid SCHEMBL23859106 0.98 BLM (0.95) BLMPMP22HSD17B10TDP1EYA2
Egtazic Acid SCHEMBL7541607 0.98 BLM (0.95) BLMPMP22HSD17B10TDP1EYA2
Egtazic Acid SCHEMBL456238 0.98 BLM (0.95) BLMPMP22HSD17B10TDP1EYA2
Egtazic Acid SCHEMBL15413556 0.98 BLM (0.95) BLMPMP22HSD17B10TDP1EYA2
Egtazic Acid SCHEMBL7200211 0.98 BLM (0.95) BLMPMP22HSD17B10TDP1EYA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 202 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3777831-B1 METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION OF PROTEINS ORAMED LTD (IL) 2023-11-29 EP disclosed
US-11660327-B2 Methods and compositions for oral administration of proteins ORAMED LTD. (IL) 2023-05-30 US disclosed
EP-4025240-A1 IL-22 ORAL, INTRA-RECTAL, OR OTHER GUT-RELATED COMPOSITIONS AND METHODS OF USE THEREOF Amgen Inc. (US) 2022-07-13 EP disclosed
US-20220160839-A1 METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION OF PROTEINS ORAMED PHARMACEUTICALS, INC. (IL) 2022-05-26 US disclosed
US-20220151919-A1 METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION ENTERA BIO LTD. (IL) 2022-05-19 US disclosed
US-11246827-B2 Methods and compositions for oral administration ENTERA BIO LTD. (IL) 2022-02-15 US disclosed
US-20210322305-A1 Methods and Compositions for Oral Administration of Exenatide ORAMED LTD. (IL) 2021-10-21 US disclosed
US-20210113663-A1 Methods and Compositions for Oral Administration of Proteins ORAMED LTD. (IL) 2021-04-22 US disclosed
WO-2021046133-A1 IL-22 ORAL, INTRA-RECTAL, OR OTHER GUT-RELATED COMPOSITIONS AND METHODS OF USE THEREOF AMGEN INC. (US) 2021-03-11 WO disclosed
EP-3777831-A1 METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION OF PROTEINS Oramed Ltd. (IL) 2021-02-17 EP disclosed
EP-1003504-A2 INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS AstraZeneca UK Limited (GB) 2000-05-31 EP disclosed
EP-1001935-A1 INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS ZENECA LIMITED (GB) 2000-05-24 EP disclosed
EP-0998564-A1 MCP-1 ANALOGS ZENECA LIMITED (GB) 2000-05-10 EP disclosed
WO-1999007351-A2 INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS ZENECA LIMITED (GB) 1999-02-18 WO disclosed
WO-1999007678-A1 INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS ZENECA LIMITED (GB) 1999-02-18 WO disclosed
WO-1999005279-A1 MCP-1 ANALOGS ZENECA LIMITED (GB) 1999-02-04 WO disclosed
EP-0703780-A4 USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE UNIV SYDNEY (AU) 1998-01-07 EP disclosed
EP-0703780-A1 USE OF NATURAL PRODUCTS AND RELATED SYNTHETIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE THE UNIVERSITY OF SYDNEY (AU) 1996-04-03 EP disclosed
US-4642284-A BINDING AGENTS, LABELS, AGGREGATION, ASSAYING SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1987-02-10 US disclosed
EP-0128696-A2 Method and apparatus for detection of complement pathway activation SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1984-12-19 EP disclosed