Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 17/20 | 0.55 |
| ▸ | PRKCA | P17252 | 3/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.53 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8970152 | 0.91 | PRKCQ (0.69) | PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL9013152 | 0.90 | PRKCQ (0.68) | PRKCQPRKCAPRKCD | |
| SCHEMBL8965423 | 0.90 | PRKCQ (0.66) | PRKCQPRKCAPRKCD | |
| SCHEMBL8964990 | 0.89 | PRKCQ (0.66) | PRKCQPRKCAPRKCD | |
| SCHEMBL8970227 | 0.89 | PRKCQ (0.53) | PRKCQPRKCAPRKCD | |
| SCHEMBL8970383 | 0.88 | PRKCQ (0.51) | PRKCQPRKCAPRKCDHSD17B14HSD11B1 | |
| SCHEMBL8970448 | 0.88 | PRKCQ (0.53) | PRKCQPRKCAPRKCDHSD17B14HSD11B1 | |
| SCHEMBL1481443 | 0.85 | PRKCQ (0.48) | PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL8970047 | 0.85 | CKS1B (0.51) | PRKCQPRKCAPRKCD | |
| SCHEMBL8970210 | 0.84 | PRKCQ (0.49) | PRKCQPRKCAPRKCDHSD17B14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |