Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 16/20 | 0.49 |
| ▸ | PRKCA | P17252 | 3/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | ME2 | P23368 | 1/20 | 0.35 |
| ▸ | ME1 | P48163 | 1/20 | 0.35 |
| ▸ | ME3 | Q16798 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1481443 | 0.93 | PRKCQ (0.48) | PRKCQPRKCAPRKCDHRH4HSD17B14 | |
| SCHEMBL8970034 | 0.89 | PRKCQ (0.49) | PRKCQPRKCAPRKCDHRH4 | |
| SCHEMBL8970047 | 0.86 | CKS1B (0.51) | PRKCQPRKCAPRKCD | |
| SCHEMBL13857202 | 0.85 | PRKCQ (0.42) | PRKCQPRKCAPRKCDHRH4HSD17B14 | |
| SCHEMBL8970017 | 0.84 | PRKCQ (0.55) | PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL8970152 | 0.83 | PRKCQ (0.69) | PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL1481470 | 0.82 | PRKCQ (0.49) | PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL11993701 | 0.82 | PRKCQ (0.63) | PRKCQPRKCAPRKCDSMO | |
| SCHEMBL8970227 | 0.81 | PRKCQ (0.53) | PRKCQPRKCAPRKCD | |
| SCHEMBL9013152 | 0.79 | PRKCQ (0.68) | PRKCQPRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |