Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 15/20 | 0.49 |
| ▸ | PRKCA | P17252 | 2/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.49 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.42 |
| ▸ | HPN | P05981 | 1/20 | 0.41 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8965024 | 0.92 | PRKCQ (0.61) | TBK1PRKCQPRKCAPRKCD | |
| SCHEMBL8970315 | 0.85 | PRKCQ (0.52) | TBK1PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL8969820 | 0.84 | PRKCQ (0.53) | PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL8965965 | 0.83 | PRKCQ (0.66) | TBK1PRKCQPRKCAPRKCD | |
| SCHEMBL8970458 | 0.82 | IKBKE (0.51) | TBK1PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL8970354 | 0.81 | PRKCQ (0.53) | PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL8970308 | 0.81 | PRKCQ (0.52) | PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL8970311 | 0.81 | PRKCQ (0.52) | PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL8970538 | 0.80 | PRKCQ (0.52) | TBK1PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL8970438 | 0.80 | PRKCQ (0.55) | PRKCQPRKCAPRKCDHSD17B14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |