Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20245163 | 0.83 | KMT2A (0.54) | KMT2AMEN1SMN1; SMN2POLBKDM4E | |
| SCHEMBL9776469 | 0.81 | SMN1; SMN2 (0.50) | KMT2AMEN1SMN1; SMN2POLBKDM4E | |
| SCHEMBL10312389 | 0.79 | KMT2A (0.51) | KMT2AMEN1SMN1; SMN2POLBKDM4E | |
| SCHEMBL10312345 | 0.76 | SMN1; SMN2 (0.51) | KMT2AMEN1SMN1; SMN2POLBKDM4E | |
| SCHEMBL8969367 | 0.76 | PDE4D (0.54) | KMT2AMEN1SMN1; SMN2POLBKDM4E | |
| SCHEMBL10263936 | 0.75 | KMT2A (0.57) | KMT2AMEN1SMN1; SMN2POLBKDM4E | |
| SCHEMBL10624008 | 0.75 | SMN1; SMN2 (0.52) | KMT2AMEN1SMN1; SMN2POLBKDM4E | |
| SCHEMBL4589513 | 0.74 | SMN1; SMN2 (0.50) | KMT2AMEN1SMN1; SMN2POLBKDM4E | |
| SCHEMBL10614317 | 0.74 | CA12 (0.58) | SMN1; SMN2KDM4ELMNAVCAM1HPGD | |
| SCHEMBL18986533 | 0.74 | LMNA (0.55) | KMT2AMEN1SMN1; SMN2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585392-A | TREATING OR PREVENTING STROKES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| US-5506246-A | Method for treating depression using substituted aminomethyltetralins and their heterocyclic analogues | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-09 | — | — | US | disclosed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| EP-0332968-B1 | 1,3,4,5-Tetrahydrobenz[c,d]indoles | BAYER AG (DE) | 1993-06-02 | — | — | EP | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0352613-A2 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1990-01-31 | — | — | EP | disclosed |
| CN-1036566-A | 1,3,4,5-tetrahydro benzo [c, d] diindyl compounds | BAYER AG (DE) | 1989-10-25 | — | — | CN | disclosed |
| EP-0332968-A1 | 1,3,4,5-Tetrahydrobenz[c,d]indoles | BAYER AG (DE) | 1989-09-20 | — | — | EP | disclosed |