Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 8/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 2/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991226 | 0.72 | OPRM1 (0.50) | OPRM1TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3252178 | 0.70 | OPRM1 (0.55) | OPRM1TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6978469 | 0.69 | OPRM1 (0.42) | OPRM1TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4522844 | 0.68 | OPRM1 (0.44) | OPRM1TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7794188 | 0.68 | SLC6A4 (0.49) | OPRM1SLC6A4SLC6A2SLC6A3TSHR | |
| SCHEMBL19226675 | 0.68 | OPRM1 (0.48) | OPRM1TACR1MEN1ALDH1A1CYP2C9 | |
| SCHEMBL31216385 | 0.68 | MAOB (0.47) | SLC6A4SLC6A2SLC6A3TSHRHTR2A | |
| SCHEMBL9790835 | 0.67 | OPRM1 (0.52) | OPRM1TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8570543 | 0.67 | EPHX1 (0.42) | OPRM1TACR1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8969997 | 0.67 | GBA1 (0.47) | SLC6A4SLC6A2SLC6A3ANPEPERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480892-A | SIGMA RECEPTOR ANTAGONISTS; TREATMENT OF PHYSIOLOGICAL OR DRUG INDUCED PSYCHOSIS AND DYSKINESIA | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-01-02 | — | — | US | disclosed |
| US-5356906-A | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| WO-1993022310-A1 | (N-PHTHALIMIDOALKYL)PIPERIDINES FOR THE TREATMENT OF PSYCHOSES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-11-11 | — | — | WO | disclosed |
| WO-1991006297-A1 | (N-PHTHALIMIDOALKYL) PIPERIDINES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-05-16 | — | — | WO | disclosed |