Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8971301 | 1.00 | TP53 (0.44) | TP53FAAHHTTALDH1A1 | |
| SCHEMBL7056869 | 0.94 | TP53 (0.45) | TP53ALDH1A1 | |
| SCHEMBL9473359 | 0.89 | TP53 (0.44) | TP53FAAH | |
| SCHEMBL8957103 | 0.89 | TP53 (0.44) | TP53 | |
| SCHEMBL8957111 | 0.89 | TP53 (0.44) | TP53 | |
| SCHEMBL8957074 | 0.89 | TP53 (0.45) | TP53 | |
| SCHEMBL8957081 | 0.89 | TP53 (0.45) | TP53 | |
| SCHEMBL8957094 | 0.87 | TP53 (0.43) | TP53 | |
| SCHEMBL8957085 | 0.87 | TP53 (0.43) | TP53 | |
| SCHEMBL9475000 | 0.85 | TP53 (0.46) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565480-A | ANGIOTENSIN II RECEPTOR ANTAGONIST; USEFUL IN REGULATING HYPERTENSION, TREATMENT OF CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLUCOMA | SMITHKLINE BEECHAM CORPORATION (US) | 1996-10-15 | — | — | US | disclosed |
| US-5444081-A | Treatment of hypertension, congestive heart failure, renal failure, glaucoma | SMITHKLINE BEECHAM CORP (US) | 1995-08-22 | — | — | US | disclosed |
| WO-1992000068-A1 | SUBSTITUTED HISTIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-09 | — | — | WO | disclosed |