Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27406264 | 0.72 | KMT2A (0.51) | TSHRALDH1A1TP53MEN1KMT2A | |
| SCHEMBL27669952 | 0.72 | TSHR (0.68) | TSHRALDH1A1KDM4ECNR2KMT2A | |
| SCHEMBL28008662 | 0.72 | TSHR (0.50) | TSHRALDH1A1CNR2KMT2AMAPK1 | |
| SCHEMBL8971537 | 0.71 | TSHR (0.49) | TSHRALDH1A1KMT2ALMNAMAPK1 | |
| SCHEMBL8971448 | 0.70 | TSHR (0.47) | TSHRALDH1A1CNR2KMT2ALMNA | |
| SCHEMBL1222681 | 0.69 | KMT2A (0.49) | TSHRALDH1A1KDM4ECNR2MEN1 | |
| SCHEMBL5163007 | 0.69 | POLB (0.44) | TSHRALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL664857 | 0.69 | ALDH1A1 (0.65) | TSHRALDH1A1MEN1KMT2AMAPK1 | |
| Benzene SCHEMBL9407299 | 0.69 | ALDH1A1 (0.65) | TSHRALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL8971482 | 0.69 | TSHR (0.50) | TSHRALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586490-B1 | DERIVATIVES OF PERHYDROISOINDOL, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE POULENC RORER SA (FR) | 1996-03-20 | — | — | EP | disclosed |
| WO-1992020653-A1 | NOVEL DERIVATIVES OF PERHYDROISOINDOL, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1992-11-26 | — | — | WO | disclosed |
| EP-0514273-A1 | New derivatives of perhydroisoindole, their preparation and pharmaceutical compositions containing them | Aventis Pharma S.A. (FR) | 1992-11-19 | — | — | EP | disclosed |