Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALPG | P10696 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9313072 | 1.00 | MAPK1 (0.40) | MAPK1CHRNA7ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9313076 | 1.00 | MAPK1 (0.40) | MAPK1CHRNA7ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8972046 | 1.00 | MAPK1 (0.40) | MAPK1CHRNA7ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8972495 | 0.85 | AHR (0.39) | MAPK1MAOBTAAR1NPSR1 | |
| SCHEMBL9312292 | 0.85 | AHR (0.39) | MAPK1MAOBTAAR1NPSR1 | |
| SCHEMBL9312294 | 0.85 | AHR (0.39) | MAPK1MAOBTAAR1NPSR1 | |
| SCHEMBL8972500 | 0.85 | AHR (0.39) | MAPK1MAOBTAAR1NPSR1 | |
| SCHEMBL9730800 | 0.84 | KDM1A (0.48) | MAPK1MAOBMAOA | |
| SCHEMBL9365368 | 0.84 | KDM1A (0.48) | MAPK1MAOBMAOA | |
| SCHEMBL9730803 | 0.84 | KDM1A (0.48) | MAPK1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433836-B1 | Halophenyl substituted dioxanes | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | disclosed |
| US-5322638-A | Halophenyl substituted dioxanes | HOFFMANN-LA ROCHE INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0433836-A2 | Halophenyl substituted dioxanes | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |