Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 13/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057734 | 0.85 | ACE (0.83) | ACEABCB11LMNAPDE3ASMN1; SMN2 | |
| SCHEMBL5981613 | 0.85 | ACE (0.83) | ACEABCB11LMNAPDE3ASMN1; SMN2 | |
| SCHEMBL682457 | 0.85 | ACE (0.83) | ACEABCB11LMNAPDE3ASMN1; SMN2 | |
| SCHEMBL16364866 | 0.85 | ACE (0.86) | ACEABCB11LMNAPDE3ASMN1; SMN2 | |
| SCHEMBL4448940 | 0.84 | ACE (0.80) | ACEABCB11LMNAPDE3A | |
| SCHEMBL7324222 | 0.83 | ACE (0.87) | ACEABCB11LMNAPDE3ASMN1; SMN2 | |
| SCHEMBL6417922 | 0.83 | ACE (0.87) | ACEABCB11LMNAPDE3ASMN1; SMN2 | |
| SCHEMBL8971446 | 0.83 | ACE (0.66) | ACEABCB11LMNAPDE3ASMN1; SMN2 | |
| Quinapril SCHEMBL11286555 | 0.83 | ACE (1.00) | ACEABCB11LMNAPDE3ASMN1; SMN2 | |
| Quinapril SCHEMBL9094436 | 0.83 | ACE (1.00) | ACEABCB11LMNAPDE3ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0175266-B1 | Antihypertensive derivatives | RHONE POULENC RORER PHARMA (US) | 1996-03-20 | — | — | EP | disclosed |
| US-4749698-A | Antihypertensive derivatives | RORER PHARMACEUTICAL CORPORATION (US) | 1988-06-07 | — | — | US | disclosed |
| EP-0175266-A2 | Antihypertensive derivatives | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1986-03-26 | — | — | EP | disclosed |