Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8972182 | 1.00 | DRD2 (0.39) | DRD2LSSSLC2A1SLC18A3HTR3A | |
| SCHEMBL9311648 | 1.00 | DRD2 (0.39) | DRD2LSSSLC2A1SLC18A3HTR3A | |
| SCHEMBL8972178 | 1.00 | DRD2 (0.39) | DRD2LSSSLC2A1SLC18A3HTR3A | |
| SCHEMBL9311652 | 1.00 | DRD2 (0.39) | DRD2LSSSLC2A1SLC18A3HTR3A | |
| SCHEMBL8038550 | 0.99 | DRD2 (0.38) | DRD2LSSSLC2A1SLC18A3HTR3A | |
| SCHEMBL9135407 | 0.96 | DRD2 (0.37) | DRD2LSSSLC2A1SLC18A3HTR3A | |
| SCHEMBL8034497 | 0.96 | DRD2 (0.37) | DRD2LSSSLC2A1SLC18A3HTR3A | |
| SCHEMBL8034490 | 0.96 | DRD2 (0.37) | DRD2LSSSLC2A1SLC18A3HTR3A | |
| SCHEMBL8034491 | 0.96 | DRD2 (0.37) | DRD2LSSSLC2A1SLC18A3HTR3A | |
| SCHEMBL9135409 | 0.96 | DRD2 (0.37) | DRD2LSSSLC2A1SLC18A3HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433836-B1 | Halophenyl substituted dioxanes | HOFFMANN LA ROCHE (CH) | 1996-03-27 | — | — | EP | disclosed |
| US-5322638-A | Halophenyl substituted dioxanes | HOFFMANN-LA ROCHE INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0433836-A2 | Halophenyl substituted dioxanes | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |