Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 2-Pyrrolidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.65 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.56 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Caprolactam SCHEMBL29173942 | 0.92 | CRBN (0.64) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL17595455 | 0.89 | OR51E2 (0.75) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL27512532 | 0.89 | OR51E2 (0.75) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL9303170 | 0.89 | OR51E2 (0.75) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL19283356 | 0.89 | OR51E2 (0.75) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL6003660 | 0.89 | OR51E2 (0.75) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL9016114 | 0.86 | OR51E2 (0.71) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL4661034 | 0.84 | OR51E2 (0.68) | OR51E2CRBNFKBP5KDM4EGAA | |
| 2-Pyrrolidone SCHEMBL28324136 | 0.84 | OR51E2 (0.68) | OR51E2CRBNFKBP5KDM4EGAA | |
| 1,6-Hexanediol SCHEMBL7071741 | 0.83 | OR51E2 (0.65) | OR51E2CRBNFKBP5KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119896617-A | Method for increasing residence of volatile substances or functional active substances on skin by using high polymer carrier | 上海奥利实业有限公司 | 2025-04-29 | — | — | CN | claimed |
| CN-115337212-A | Composition for relieving itching, removing dandruff and controlling oil and application thereof | 博汇美萃生物工程技术(广东)有限公司 | 2022-11-15 | — | — | CN | claimed |
| CN-115317414-A | Chinese herbal medicine shampoo and preparation method thereof | 罗红 | 2022-11-11 | — | — | CN | claimed |
| CN-114886818-A | Anti-dandruff composition, shampoo and preparation method thereof | 安福超威日化有限公司 | 2022-08-12 | — | — | CN | claimed |
| CN-113413357-A | Probiotic composition and application thereof | 卡莱丽化妆品有限公司 | 2021-09-21 | — | — | CN | claimed |
| CN-104000749-A | Scalp nursing solution | NICE GROUP CO LTD | 2014-08-27 | — | — | CN | claimed |
| CN-119896617-A | Method for increasing residence of volatile substances or functional active substances on skin by using high polymer carrier | 上海奥利实业有限公司 | 2025-04-29 | — | — | CN | disclosed |
| CN-119792163-A | Composition with oil control effect | 广州美兮生物科技有限公司 | 2025-04-11 | — | — | CN | disclosed |
| CN-115337212-B | Composition for relieving itching, removing dandruff and controlling oil and application thereof | 博汇美萃生物工程技术(广东)有限公司 | 2024-08-20 | — | — | CN | disclosed |
| CN-114053183-B | Composition with multi-target scalp itching relieving effect | 深圳市兰亭科技股份有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-116725921-A | Oil-control and anti-dandruff composition, oil-control and anti-dandruff shampoo and preparation method thereof | 香鉴香氛科技研发(广州)有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-115957252-A | Scalp oil-removing, itching-relieving and sterilizing composition and ointment thereof | 李晶晶 | 2023-04-14 | — | — | CN | disclosed |
| CN-111920726-B | Multi-effect quick scalp itching relieving composition, preparation method thereof and shampoo composition | 广州德谷个人护理用品有限公司 | 2023-01-10 | — | — | CN | disclosed |
| CN-101342122-B | Aqueous liquid photoprotective composition based on a polyamide polymer with tertiary amide termination | OREAL | 2013-01-23 | — | — | CN | disclosed |
| CN-101336871-B | Sun-protection composition containing the association of a semi-crystalline polymer and hollow latex particles | OREAL | 2011-11-09 | — | — | CN | disclosed |
| CN-101342122-A | Aqueous liquid photoprotective composition based on a polyamide polymer with tertiary amide termination | OREAL (FR) | 2009-01-14 | — | — | CN | disclosed |
| CN-101336871-A | Sun-protection composition containing the association of a semi-crystalline polymer and hollow latex particles | OREAL (FR) | 2009-01-07 | — | — | CN | disclosed |
| CN-1142625-A | Photoconductor for electrophotography and method for fabricating the same | FUJI ELECTRIC CO LTD (JP) | 1997-02-12 | — | — | CN | disclosed |
| EP-0703501-A1 | Photoconductor for electro-photography and a method for fabricating the same | FUJI ELECTRIC CO., LTD. (JP) | 1996-03-27 | — | — | EP | disclosed |
| US-4839332-A | AMINO-SUBSTITUTED FLUORENE AND ACID; DISCOLORATION INHIBITON, CHEMICAL RESISTANCE | FUJI PHOTO FILM CO., LTD. (JP) | 1989-06-13 | — | — | US | disclosed |