Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9549804 | 0.95 | TSHR (0.50) | TSHRCYP2C19ALDH1A1CYP1A2CYP2D6 | |
| Acetic Acid SCHEMBL9549770 | 0.95 | TSHR (0.50) | TSHRCYP2C19ALDH1A1CYP1A2CYP2D6 | |
| Acetic Acid SCHEMBL9848332 | 0.93 | TSHR (0.49) | TSHRCYP2C19ALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL143506 | 0.87 | HIF1A (0.58) | TSHRCYP2C19ALDH1A1CYP1A2CYP2D6 | |
| Iodide SCHEMBL9549744 | 0.87 | HIF1A (0.58) | TSHRCYP2C19ALDH1A1CYP1A2CYP2D6 | |
| Water SCHEMBL8528580 | 0.87 | HIF1A (0.58) | TSHRCYP2C19ALDH1A1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL9549567 | 0.87 | HIF1A (0.58) | TSHRCYP2C19ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8532850 | 0.87 | HIF1A (0.58) | TSHRCYP2C19ALDH1A1CYP1A2CYP2D6 | |
| Phosphoric Acid SCHEMBL8972371 | 0.86 | HTR2A (0.50) | TSHRCYP2C19ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8972950 | 0.85 | HIF1A (0.52) | TSHRCYP2C19ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061998-C | Process for producing aromatic polycarbonate | MITSUBISHI CHEM CORP (JP) | 2001-02-14 | — | — | CN | disclosed |
| US-5578694-A | MELT POLYCONDENSATION OF AROMATIC DIOL AND DIARYL CARBONATE; ESTER INTERCHANGE USING PHOSPHONIUM CATALYST | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-11-26 | — | — | US | disclosed |
| CN-1127265-A | Process for producing aromatic polycarbonate | MITSUBISHI CHEM CORP (JP) | 1996-07-24 | — | — | CN | disclosed |
| EP-0703262-A2 | Process for producing aromatic polycarbonate | Mitsubishi Chemical Corporation (JP) | 1996-03-27 | — | — | EP | disclosed |