Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 6/20 | 0.47 |
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 0.47 |
| ▸ | CHRM1 known ✓ | P11229 | 5/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 5/20 | 0.46 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.58 |
| ▸ | HRH1 | P35367 | 8/20 | 0.57 |
| ▸ | HTR2A | P28223 | 7/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.47 |
| ▸ | SCN1A | P35498 | 4/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.46 |
| ▸ | HRH2 | P25021 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL8528580 | 0.96 | HIF1A (0.58) | HIF1AHRH1HTR2ACHRM2SLC6A2 | |
| SCHEMBL8532850 | 0.96 | HIF1A (0.58) | HIF1AHRH1HTR2ACHRM2SLC6A2 | |
| Bromide SCHEMBL143506 | 0.96 | HIF1A (0.58) | HIF1AHRH1HTR2ACHRM2SLC6A2 | |
| Iodide SCHEMBL9549744 | 0.96 | HIF1A (0.58) | HIF1AHRH1HTR2ACHRM2SLC6A2 | |
| SCHEMBL8972950 | 0.90 | HIF1A (0.52) | HIF1AHRH1HTR2ACHRM2SLC6A2 | |
| Hydrochloric Acid SCHEMBL8861752 | 0.88 | HTR2A (0.60) | HIF1AHRH1HTR2ACHRM2SLC6A2 | |
| Phosphoric Acid SCHEMBL8972371 | 0.87 | HTR2A (0.50) | HIF1AHRH1HTR2ACHRM2SLC6A2 | |
| Bicarbonate SCHEMBL8973196 | 0.87 | TSHR (0.52) | HIF1AHRH1HTR2ACHRM2SLC6A2 | |
| Hydrochloric Acid SCHEMBL9549516 | 0.86 | HTR2A (0.53) | HIF1AHRH1HTR2ACHRM2SLC6A2 | |
| Oxalic Acid SCHEMBL9549804 | 0.85 | TSHR (0.50) | HIF1AHRH1HTR2ACHRM2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208317-A | Molding materials of cured epoxy resins | THE DOW CHEMICAL COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| US-5109099-A | ADVANCING EPOXY RESINS IN PRESENCE OF AMINO GROUP-CONTAINING PHOSPHONIUM CATALYST | THE DOW CHEMICAL COMPANY (US) | 1992-04-28 | — | — | US | disclosed |
| EP-0441243-A2 | Precatalyzed catalyst compositions, process for preparing epoxy resins, curable compositions, articles resulting from curing the resultant compositions | THE DOW CHEMICAL COMPANY (US) | 1991-08-14 | — | — | EP | disclosed |
| US-4981926-A | Rapid and selective curing using phosphonium catalyst containing an amine group; polyepoxides | THE DOW CHEMICAL COMPANY (US) | 1991-01-01 | — | — | US | disclosed |
| US-4654352-A | AMINO SUBSTITUTED | PFIZER INC. (US) | 1987-03-31 | — | — | US | disclosed |
| EP-0169012-A1 | Benzothiophene anti-diarrhoeal agents | Pfizer Limited (GB) | 1986-01-22 | — | — | EP | disclosed |