Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974083 | 0.86 | PTGDR2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL8973806 | 0.86 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL8974810 | 0.85 | PTGS1 (0.51) | PTGS2PTGS1 | |
| SCHEMBL8974558 | 0.84 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL8974512 | 0.84 | PTGS2 (0.52) | PTGS2PTGS1AKR1C3 | |
| SCHEMBL8973860 | 0.81 | PTGS2 (0.35) | PTGS2PTGS1 | |
| SCHEMBL8974297 | 0.81 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL8974256 | 0.81 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL8974314 | 0.79 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL8974629 | 0.77 | PTGS2 (0.54) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |