SCHEMBL8974754

SCHEMBL8974754

CCOC(=O)c1cc(O)nc(Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.56
CA1 P00915 3/20 0.56
CA2 P00918 3/20 0.56
CA7 P43166 3/20 0.56
CA9 Q16790 3/20 0.56
CA14 Q9ULX7 3/20 0.56
ESR1 P03372 2/20 0.47
ESR2 Q92731 1/20 0.47
BCL2L1 Q07817 1/20 0.46
CYP2C19 P33261 2/20 0.45
CYP2C9 P11712 1/20 0.45
KMT2A Q03164 3/20 0.44
ALDH1A1 P00352 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CYP1A2 P05177 2/20 0.43
CYP2D6 P10635 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
PTPN11 Q06124 1/20 0.43
GPR119 Q8TDV5 1/20 0.43
HSD17B2 P37059 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL851862 0.90 CA12 (0.58) CA12CA1CA2CA7CA9
SCHEMBL11219628 0.88 CA12 (0.66) CA12CA1CA2CA7CA9
SCHEMBL1179728 0.85 CA12 (0.53) CA12CA1CA2CA7CA9
SCHEMBL2085156 0.83 CA12 (0.59) CA12CA1CA2CA7CA9
SCHEMBL29965908 0.82 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL15321600 0.82 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL17053329 0.82 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL2532558 0.82 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL1314039 0.81 GPR119 (0.49) CA12CA1CA2CA7CA9
SCHEMBL1179421 0.81 SMN1; SMN2 (0.55) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-8208613-A None JP disclosed
JP-H08208613-A 2-CHLORO-6-HYDROXYISONICOTINIC ACID DERIVATIVE AND PLANT DISEASE INJURY-CONTROLLING AGENT DAINIPPON INK & CHEM INC 1996-08-13 JP disclosed