Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 9/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 4/20 | 0.36 |
| ▸ | MPC2 | O95563 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8975224 | 0.92 | GRM2 (0.45) | GRM2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8857152 | 0.80 | GRM2 (0.57) | GRM2CA2 | |
| SCHEMBL8857181 | 0.77 | GRM2 (0.51) | GRM2CA2 | |
| SCHEMBL8974648 | 0.77 | PPARG (0.49) | GRM2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8975396 | 0.77 | PPARG (0.49) | GRM2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8975188 | 0.77 | PPARG (0.49) | GRM2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8974643 | 0.77 | PPARG (0.49) | GRM2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8975392 | 0.77 | PPARG (0.49) | GRM2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8975354 | 0.77 | PPARG (0.49) | GRM2PPARGMPC2CYP2C8CYP2C9 | |
| SCHEMBL8975359 | 0.77 | PPARG (0.49) | GRM2PPARGMPC2CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578620-A | TREATMENT OF DIABETES AND HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 1996-11-26 | — | — | US | disclosed |
| EP-0678511-A2 | Thiazolidine and oxazolidine derivatives, their preparation and their medical use | SANKYO COMPANY LIMITED (JP) | 1995-10-25 | — | — | EP | disclosed |