Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17180879 | 0.80 | CA1 (0.48) | CA4LTA4HTSHRMAPK1ALDH1A1 | |
| SCHEMBL10891935 | 0.78 | PPARA (0.40) | TSHRMAPK1ALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL20718949 | 0.77 | TSHR (0.36) | CA4LTA4HTSHRALDH1A1KCNA3 | |
| SCHEMBL4786956 | 0.77 | TSHR (0.36) | CA4LTA4HTSHRKCNA3CA5A | |
| SCHEMBL9421959 | 0.77 | LTA4H (0.50) | CA4LTA4HTSHRALDH1A1ALOX15 | |
| SCHEMBL3691784 | 0.76 | CA4 (0.42) | CA4LTA4HTSHRMAPK1RIPK1 | |
| SCHEMBL237878 | 0.73 | CA4 (0.43) | CA4LTA4HTSHRRIPK1KCNA3 | |
| SCHEMBL7085752 | 0.71 | CA4 (0.48) | CA4LTA4HTSHRTDP1MAPT | |
| SCHEMBL8214072 | 0.69 | LTA4H (0.41) | CA4LTA4HTSHRALDH1A1ALOX15 | |
| SCHEMBL7391389 | 0.69 | LTA4H (0.41) | CA4LTA4HTSHRALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543919-B1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS IN THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF CNS DISEASES | SEARLE & CO (US) | 1996-04-10 | — | — | EP | claimed |