Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.58 |
| ▸ | PDE4A | P27815 | 13/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | VEGFA | P15692 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | PDE1A | P54750 | 1/20 | 0.57 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8975928 | 0.90 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL9222093 | 0.85 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL9219458 | 0.82 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL16785446 | 0.80 | FPR1 (0.58) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL29434228 | 0.80 | FPR1 (0.58) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL18579317 | 0.80 | FPR1 (0.58) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL14003224 | 0.79 | PDE4D (0.58) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL7366496 | 0.79 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7366497 | 0.79 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8975957 | 0.78 | PDE4A (0.61) | PDE4BPDE4APDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5539111-A | Process for resolution of racemates of 4-aryl-2-oxo-pyrrolidine-3-carboxylic acid esters | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-07-23 | — | — | US | disclosed |