Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.69 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.58 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.51 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30638097 | 0.83 | EGFR (0.59) | EGFRALKMAPTHTTABCG2 | |
| SCHEMBL157043 | 0.83 | EGFR (0.59) | EGFRALKMAPTHTTABCG2 | |
| SCHEMBL1192454 | 0.82 | EGFR (1.00) | EGFRALKALDH1A1MAPTHTT | |
| SCHEMBL8976408 | 0.81 | EGFR (1.00) | EGFRALDH1A1MAPTHTTERBB2 | |
| SCHEMBL4587672 | 0.81 | ALK (0.79) | EGFRALKALDH1A1MAPTHTT | |
| SCHEMBL159107 | 0.80 | EGFR (0.68) | EGFRABCG2ERBB2ERBB4 | |
| SCHEMBL18349251 | 0.80 | EGFR (0.77) | EGFRALKALDH1A1MAPTHTT | |
| SCHEMBL3244626 | 0.80 | ALK (0.77) | EGFRALKALDH1A1MAPTHTT | |
| Hydrochloric Acid SCHEMBL8976403 | 0.79 | EGFR (0.67) | EGFRALKALDH1A1MAPTHTT | |
| SCHEMBL8976740 | 0.79 | EGFR (0.69) | EGFRALKALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| CN-1094043-A | Quinazoline derivant | ZENECA LTD (GB) | 1994-10-26 | — | — | CN | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |