Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 1.00 |
| ▸ | KDR | P35968 | 7/20 | 1.00 |
| ▸ | RAF1 | P04049 | 1/20 | 0.70 |
| ▸ | BRAF | P15056 | 1/20 | 0.70 |
| ▸ | EGFR | P00533 | 11/20 | 0.66 |
| ▸ | CLK1 | P49759 | 1/20 | 0.66 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 3/20 | 0.65 |
| ▸ | KIF5B | P33176 | 2/20 | 0.63 |
| ▸ | FLT1 | P17948 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.60 |
| ▸ | STK10 | O94804 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.60 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.60 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.60 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181034 | 0.91 | RET (1.00) | RETKDREGFRCLK1ABCG2 | |
| Hydrochloric Acid SCHEMBL6179218 | 0.90 | RET (0.98) | RETKDREGFRCLK1ABCG2 | |
| SCHEMBL14699312 | 0.86 | RET (0.75) | RETKDRRAF1BRAFEGFR | |
| SCHEMBL4379466 | 0.84 | SRC (0.72) | RETKDRBRAFEGFRABCG2 | |
| SCHEMBL15051600 | 0.83 | RAF1 (1.00) | RETKDRRAF1BRAF | |
| SCHEMBL8976728 | 0.83 | RET (1.00) | RETKDREGFRCLK1ABCG2 | |
| SCHEMBL30264460 | 0.82 | EGFR (0.74) | RETKDREGFR | |
| Hydrochloric Acid SCHEMBL6432540 | 0.81 | RET (0.68) | RETKDRRAF1BRAFEGFR | |
| SCHEMBL5565137 | 0.80 | EGFR (1.00) | RETKDREGFRCLK1ABCG2 | |
| SCHEMBL8524535 | 0.80 | EGFR (0.82) | RETKDRRAF1BRAFEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |