Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.82 |
| ▸ | RET | P07949 | 2/20 | 0.67 |
| ▸ | KDR | P35968 | 1/20 | 0.67 |
| ▸ | RAF1 | P04049 | 1/20 | 0.65 |
| ▸ | BRAF | P15056 | 1/20 | 0.65 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096187 | 0.90 | EGFR (1.00) | EGFRRETKDRRAF1BRAF | |
| SCHEMBL29680961 | 0.83 | RET (0.64) | EGFRRETKDRRAF1BRAF | |
| SCHEMBL8081980 | 0.81 | EGFR (1.00) | EGFRRETERBB2 | |
| SCHEMBL8976347 | 0.80 | RET (1.00) | EGFRRETKDRRAF1BRAF | |
| SCHEMBL15051600 | 0.79 | RAF1 (1.00) | RETKDRRAF1BRAF | |
| SCHEMBL2103341 | 0.78 | EGFR (0.82) | EGFRERBB2 | |
| SCHEMBL5565174 | 0.77 | MKNK1 (0.51) | EGFRRETKDRRAF1BRAF | |
| SCHEMBL8093519 | 0.77 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL22946710 | 0.76 | EGFR (0.62) | EGFRRETKDRRAF1BRAF | |
| SCHEMBL2835747 | 0.75 | EGFR (0.74) | EGFRRETKDRRAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |