Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.78 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.78 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.78 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.78 |
| ▸ | ABL1 | P00519 | 1/20 | 0.78 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.78 |
| ▸ | PIM1 | P11309 | 1/20 | 0.78 |
| ▸ | PRKACA | P17612 | 1/20 | 0.78 |
| ▸ | LTK | P29376 | 1/20 | 0.78 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.78 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.78 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.78 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.78 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.78 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.78 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.78 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.78 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.78 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.78 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941271 | 0.88 | EGFR (1.00) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| SCHEMBL8920 | 0.88 | EGFR (1.00) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| Hydrochloric Acid SCHEMBL29394578 | 0.86 | EGFR (0.96) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| SCHEMBL6829578 | 0.86 | EGFR (0.66) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| Hydrochloric Acid SCHEMBL20856873 | 0.86 | EGFR (0.96) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| SCHEMBL300638 | 0.84 | EGFR (0.58) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| SCHEMBL6823372 | 0.83 | EGFR (0.77) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| Hydrochloric Acid SCHEMBL8808235 | 0.83 | EGFR (0.90) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| SCHEMBL5675946 | 0.83 | EGFR (0.62) | EGFRABCG2DAPK3MAP4K4ABL1 | |
| SCHEMBL6831353 | 0.83 | EGFR (0.62) | EGFRABCG2DAPK3MAP4K4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | claimed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | claimed |
| EP-0700382-A1 | NOVEL N-ARYLALIPHATIC-N-ALKYL-FUNCTIONALISED AMIDES, METHOD FOR THEIR PREPATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI (FR) | 1996-03-13 | — | — | EP | claimed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | claimed |
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0700382-A1 | NOVEL N-ARYLALIPHATIC-N-ALKYL-FUNCTIONALISED AMIDES, METHOD FOR THEIR PREPATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI (FR) | 1996-03-13 | — | — | EP | disclosed |
| CN-1094043-A | Quinazoline derivant | ZENECA LTD (GB) | 1994-10-26 | — | — | CN | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |