Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 15/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 15/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 14/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 14/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 14/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 14/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 14/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 14/20 | 0.69 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23774505 | 0.85 | PDE4B (0.57) | HDAC1HDAC2HDAC10HDAC8HDAC6 | |
| SCHEMBL26355712 | 0.85 | HDAC3 (0.69) | HDAC1HDAC2HDAC10HDAC8HDAC6 | |
| SCHEMBL11815716 | 0.84 | SRC (0.61) | HDAC1HDAC2HDAC10HDAC8HDAC6 | |
| SCHEMBL30556704 | 0.81 | SRC (0.58) | HDAC1HDAC2HDAC10HDAC8HDAC6 | |
| SCHEMBL26328679 | 0.81 | SRC (0.62) | HDAC1HDAC2HDAC10HDAC8HDAC6 | |
| SCHEMBL22959003 | 0.81 | SRC (0.58) | HDAC1HDAC2HDAC10HDAC8HDAC6 | |
| SCHEMBL15863726 | 0.80 | SRC (0.82) | HDAC1HDAC2HDAC10HDAC8HDAC6 | |
| SCHEMBL19933784 | 0.79 | HDAC3 (0.52) | HDAC1HDAC2HDAC10HDAC8HDAC6 | |
| SCHEMBL28330048 | 0.78 | CYP19A1 (0.60) | HDAC1HDAC2HDAC10HDAC8HDAC6 | |
| SCHEMBL28397299 | 0.75 | SRC (0.59) | HDAC1HDAC2HDAC10HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871728-B2 | Non-peptide macrocyclic histone deacetylese (HDAC) inhibitors and methods of making and using thereof | GEORGIA TECH RESEARCH CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20120329741-A1 | NON-PEPTIDE MACROCYCLIC HISTONE DEACETYLASE (HDAC) INHIBITORS AND METHODS OF MAKING AND USING THEREOF | GEORGIA TECH RESEARCH CORPORATION | 2012-12-27 | — | — | US | disclosed |
| US-8188054-B2 | Non-peptide macrocyclic histone deacetylase (HDAC) inhibitors and methods of making and using thereof | GEORGIA TECH RESEARCH CORPORATION (US) | 2012-05-29 | — | — | US | disclosed |
| US-20100197622-A1 | Non-Peptide Macrocyclic Histone Deacetylase (HDAC) Inhibitors and Methods of Making and Using Thereof | GEORGIA TECH RESEARCH CORPORATION | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197622-A1 | Non-Peptide Macrocyclic Histone Deacetylase (HDAC) Inhibitors and Methods of Making and Using Thereof | HDAC5, HDAC3, HDAC1 | HDAC1 3/4885HDAC2 10/4885HDAC10 8/4885 |
| US-20120329741-A1 | NON-PEPTIDE MACROCYCLIC HISTONE DEACETYLASE (HDAC) INHIBITORS AND METHODS OF MAKING AND USING THEREOF | HDAC5, HDAC3, HDAC1 | HDAC1 3/4885HDAC2 10/4885HDAC10 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.