Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467379 | 0.88 | MRGPRX4 (0.49) | MRGPRX4BRD4PDE5APDE1APDE1B | |
| SCHEMBL8260068 | 0.81 | MRGPRX4 (0.51) | MRGPRX4PARP1BRD4CYP1A2MAPT | |
| SCHEMBL8777276 | 0.78 | KCNH2 (0.41) | CYP3A4SMN1; SMN2 | |
| SCHEMBL22002661 | 0.77 | MRGPRX4 (0.58) | MRGPRX4PARP1BRD4CYP1A2MAPT | |
| SCHEMBL31288949 | 0.77 | PDE5A (0.61) | MRGPRX4PDE5APDE1APDE1BPDE1C | |
| SCHEMBL9174404 | 0.76 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30746942 | 0.76 | MAPK1 (0.46) | MAPTNPC1RAB9ASMN1; SMN2ABL1 | |
| SCHEMBL7479219 | 0.76 | MEN1 (0.40) | PDE5AGAANPC1CYP2C9RAB9A | |
| SCHEMBL4134240 | 0.75 | KCNH2 (0.38) | CYP3A4SMN1; SMN2ABL1 | |
| SCHEMBL5466687 | 0.75 | MRGPRX4 (0.55) | MRGPRX4PARP1BRD4CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559134-A | Leukotriene-B4 antagonists, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-09-24 | — | — | US | disclosed |