Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19150272 | 1.00 | HTR6 (0.45) | HTR6CHRNB2CHRNA7CHRNA4EPHX1 | |
| SCHEMBL2180885 | 0.86 | HTR6 (0.46) | HTR6CHRNB2CHRNA7CHRNA4HTR1D | |
| SCHEMBL1697459 | 0.86 | HTR6 (0.46) | HTR6CHRNB2CHRNA7CHRNA4HTR1D | |
| SCHEMBL19540506 | 0.82 | HTR6 (0.44) | HTR6EPHX1 | |
| SCHEMBL8979689 | 0.82 | HTR6 (0.40) | HTR6EPHX1L3MBTL1HTR1DHTR1B | |
| SCHEMBL6967984 | 0.81 | HTR6 (0.49) | HTR6CHRNB2CHRNA7CHRNA4HTR1D | |
| SCHEMBL6965704 | 0.81 | HTR6 (0.49) | HTR6CHRNB2CHRNA7CHRNA4HTR1D | |
| SCHEMBL6965707 | 0.81 | HTR6 (0.49) | HTR6CHRNB2CHRNA7CHRNA4HTR1D | |
| SCHEMBL14077946 | 0.80 | HTR6 (0.56) | HTR6EPHX1L3MBTL1KRAS | |
| SCHEMBL19170911 | 0.79 | HTR6 (0.50) | HTR6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017125351-A1 | PROCESS FOR PREPARING (( R)-3-[(-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-(2-PHENYLSULFONYLETHYL)-1H-INDOLE | LABORATORIOS LESVI SL (ES) | 2017-07-27 | — | — | WO | disclosed |
| WO-2017125351-A1 | PROCESS FOR PREPARING (( R)-3-[(-1-METHYLPYRROLIDIN-2-YL)METHYL]-5-(2-PHENYLSULFONYLETHYL)-1H-INDOLE | LABORATORIOS LESVI SL (ES) | 2017-07-27 | — | — | WO | disclosed |
| US-5502065-A | TREATING HEADACHES | PFIZER INC. (US) | 1996-03-26 | — | — | US | disclosed |
| CN-1082040-A | Indoles | PFIZER RES & DEV (IE) | 1994-02-16 | — | — | CN | disclosed |
| WO-1993021178-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |