Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 15/20 | 0.64 |
| ▸ | HTR1D | P28221 | 12/20 | 0.64 |
| ▸ | HTR1A | P08908 | 3/20 | 0.60 |
| ▸ | HTR6 | P50406 | 5/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9545526 | 0.84 | HTR1B (0.63) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL8979699 | 0.82 | HTR1B (0.58) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL9545537 | 0.81 | HTR1B (0.57) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL8979710 | 0.81 | HTR1B (0.57) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL8979724 | 0.80 | HTR1B (0.55) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL8507160 | 0.79 | HTR1B (1.00) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8507164 | 0.79 | HTR1B (1.00) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8979727 | 0.78 | CHRM2 (0.39) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL7612794 | 0.78 | HTR1B (0.64) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8790804 | 0.77 | HTR1B (0.72) | HTR1BHTR1DHTR1AHTR6CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502065-A | TREATING HEADACHES | PFIZER INC. (US) | 1996-03-26 | — | — | US | disclosed |
| WO-1993021178-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |