Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 10/20 | 0.38 |
| ▸ | HTR1D | P28221 | 8/20 | 0.38 |
| ▸ | HTR6 | P50406 | 5/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8979734 | 0.82 | HTR6 (0.38) | HTR1BHTR1DHTR6HTR1A | |
| SCHEMBL8979729 | 0.82 | HTR6 (0.37) | HTR6 | |
| SCHEMBL8979708 | 0.78 | HTR1B (0.64) | CHRM2CHRM1HTR1BHTR1DHTR6 | |
| SCHEMBL8979695 | 0.76 | HTR6 (0.38) | HTR1BHTR1DHTR6 | |
| SCHEMBL8979687 | 0.76 | HTR6 (0.43) | HTR1BHTR1DHTR6 | |
| SCHEMBL8979723 | 0.70 | HTR6 (0.39) | HTR1BHTR1DHTR6 | |
| SCHEMBL7010546 | 0.64 | HTR6 (0.44) | HTR1BHTR1DHTR6 | |
| SCHEMBL7010544 | 0.64 | HTR6 (0.44) | HTR1BHTR1DHTR6 | |
| SCHEMBL7012792 | 0.64 | HTR6 (0.44) | HTR1BHTR1DHTR6 | |
| SCHEMBL8979699 | 0.63 | HTR1B (0.58) | HTR1BHTR1DHTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502065-A | TREATING HEADACHES | PFIZER INC. (US) | 1996-03-26 | — | — | US | disclosed |
| EP-0636129-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | Pfizer Limited (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021178-A1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |