Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | BDKRB1 | P46663 | 4/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8979781 | 0.95 | AGTR1 (0.48) | BRS3BDKRB1LTB4R2ACHEAGTR1 | |
| SCHEMBL8979771 | 0.89 | BRS3 (0.49) | BRS3AGTR1AGTR2 | |
| SCHEMBL8979910 | 0.85 | BRS3 (0.46) | BRS3SLC6A3SLC6A4BDKRB1LTB4R2 | |
| SCHEMBL8979747 | 0.84 | BRS3 (0.54) | BRS3AGTR1AGTR2 | |
| SCHEMBL8979783 | 0.81 | AGTR1 (0.48) | BRS3BDKRB1LTB4R2ACHEAGTR1 | |
| SCHEMBL8668602 | 0.79 | BDKRB1 (0.43) | BRS3SLC6A3SLC6A4BDKRB1LTB4R2 | |
| SCHEMBL8979758 | 0.79 | AGTR1 (0.49) | BRS3SLC6A3SLC6A4BDKRB1LTB4R2 | |
| SCHEMBL8979872 | 0.79 | AGTR1 (0.49) | BRS3BDKRB1LTB4R2ACHEAGTR1 | |
| SCHEMBL8673612 | 0.78 | AGTR1 (0.49) | BRS3BDKRB1LTB4R2ACHEAGTR1 | |
| SCHEMBL9136676 | 0.78 | AGTR1 (0.49) | BRS3BDKRB1LTB4R2ACHEAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565464-A | Compounds having angiotensine II antagonistic activity | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1996-10-15 | — | — | US | disclosed |
| WO-1993003018-A1 | COMPOUNDS HAVING ANGIOTENSINE II ANTAGONISTIC ACTIVITY | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1993-02-18 | — | — | WO | disclosed |