Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29833583 | 0.89 | HTT (0.60) | HTTSMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL890785 | 0.89 | HTT (0.60) | HTTSMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL6200815 | 0.88 | HTT (0.58) | HTTSMN1; SMN2MAPTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL11776690 | 0.88 | HTT (0.58) | HTTSMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL11776685 | 0.88 | HTT (0.58) | HTTSMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL11314343 | 0.85 | ALDH1A1 (0.64) | HTTSMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL11526803 | 0.85 | HTT (0.71) | HTTSMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL12202770 | 0.84 | AR (0.55) | HTTSMN1; SMN2LMNAMAPK1ALDH1A1 | |
| SCHEMBL358355 | 0.82 | HTT (0.63) | HTTSMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL3164500 | 0.82 | ALDH1A1 (0.66) | HTTSMN1; SMN2MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |