Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.69 |
| ▸ | RAB9A | P51151 | 5/20 | 0.69 |
| ▸ | PLAU | P00749 | 2/20 | 0.69 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26613421 | 0.87 | NPC1 (0.55) | NPC1RAB9APLAUPABPC1KMT2A | |
| SCHEMBL26613556 | 0.84 | PLAU (0.52) | NPC1RAB9APLAUPABPC1MAPT | |
| SCHEMBL26613551 | 0.84 | KMT2A (0.59) | NPC1RAB9APABPC1KMT2AMEN1 | |
| SCHEMBL2176831 | 0.82 | NPC1 (1.00) | NPC1RAB9APLAUPABPC1KMT2A | |
| SCHEMBL26613478 | 0.81 | ADORA1 (0.57) | NPC1RAB9APLAUKMT2AMEN1 | |
| SCHEMBL20741553 | 0.80 | NPC1 (0.51) | NPC1RAB9APLAUPABPC1KMT2A | |
| SCHEMBL29746102 | 0.79 | NPC1 (0.53) | NPC1RAB9APLAUKMT2AMEN1 | |
| SCHEMBL26613566 | 0.79 | NPC1 (0.53) | NPC1RAB9APLAUKMT2AMEN1 | |
| SCHEMBL3202307 | 0.79 | NPC1 (0.46) | NPC1RAB9APLAUPABPC1KMT2A | |
| SCHEMBL24609656 | 0.79 | SERPINE1 (0.53) | NPC1RAB9APLAUKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |