SCHEMBL8980371

SCHEMBL8980371

C=CCOC(=O)C1(CC=C)CCCC1=O

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.33
ALDH1A1 P00352 3/20 0.31
GAA P10253 1/20 0.31
NPSR1 Q6W5P4 2/20 0.30
KDM4E B2RXH2 1/20 0.30
HPGD P15428 1/20 0.30
TSHR P16473 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31695088 0.87 CYP2C19 (0.39) CYP3A4ALDH1A1TSHR
SCHEMBL5180173 0.87 CYP2C19 (0.39) CYP3A4ALDH1A1TSHR
SCHEMBL10954179 0.86 ALDH1A1 (0.30) ALDH1A1TSHR
SCHEMBL10954184 0.86 ALDH1A1 (0.30) ALDH1A1TSHR
SCHEMBL9732373 0.83 CYP2C19 (0.34) CYP3A4ALDH1A1NPSR1KDM4ETSHR
SCHEMBL25619136 0.82 CYP2C19 (0.36) CYP3A4ALDH1A1TSHR
SCHEMBL1137710 0.82 CYP2C19 (0.36) CYP3A4ALDH1A1TSHR
SCHEMBL18101495 0.82 TSHR (0.33) CYP3A4ALDH1A1TSHR
SCHEMBL10798085 0.82 TSHR (0.42) CYP3A4ALDH1A1HPGDTSHR
SCHEMBL7624802 0.81 CYP2C19 (0.35) CYP3A4ALDH1A1KDM4ETSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0712836-A1 Alkyl 3-benzylidene-1-alkyl-2-oxocyclopentanecarboxylate derivates as fungicides KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1996-05-22 EP claimed
JP-7082219-A None JP disclosed
JP-56142232-A None JP disclosed
EP-0712836-A1 Alkyl 3-benzylidene-1-alkyl-2-oxocyclopentanecarboxylate derivates as fungicides KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1996-05-22 EP disclosed
US-5519160-A FUNGICIDES KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1996-05-21 US disclosed
JP-H0782219-A 3-(UNSUBSTITUTED OR SUBSTITUTED BENZYLIDENE)-1-ALKYL-2-OXOCYCLOPENTANECARBOXYLIC ACID ALKYL ESTER DERIVATIVE, ITS PRODUCTION AND ITS USE AS FUNGICIDE AND INTERMEDIATE KUREHA CHEM IND CO LTD 1995-03-28 JP disclosed
US-5258404-A 3-(Unsubstituted or substituted benzyl)-1-alkyl-2-oxocyclopentane carboxylic acid alkyl ester derivatives, method for preparation fungicides, and use thereof as intermediate compounds KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1993-11-02 US disclosed
JP-S56142232-A PREPARATION OF 2-ALKYL-4-CYCLOPENTEN-1-ONE AGENCY OF IND SCIENCE & TECHNOL 1981-11-06 JP disclosed