SCHEMBL898040

SCHEMBL898040

O=C1c2ccc(O)cc2Cc2oc3ccccc3c21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C9 P11712 1/20 0.47
HPGD P15428 1/20 0.47
CYP2C19 P33261 1/20 0.47
MAOA P21397 12/20 0.46
MAOB P27338 11/20 0.46
ALOX5 P09917 1/20 0.42
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA4 P22748 1/20 0.41
CA6 P23280 1/20 0.41
TYR P14679 1/20 0.40
POLB P06746 2/20 0.40
USP2 O75604 1/20 0.40
ATM Q13315 1/20 0.40
PLEC Q15149 1/20 0.40
NPC1 O15118 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL898590 0.84 MAOA (0.46) MEN1KMT2AMAOAMAOBTYR
SCHEMBL17434684 0.83 MAOA (0.48) KDM4EMEN1KMT2ACYP3A4HPGD
SCHEMBL898463 0.82 NPC1 (0.50) KDM4ECYP3A4HPGDMAOAMAOB
SCHEMBL898640 0.71 ALK (0.61)
SCHEMBL898290 0.71 ALK (0.61) KDM4EMEN1KMT2ACYP3A4CYP2C9
SCHEMBL29962984 0.70 CA1 (0.57) MEN1KMT2AMAOAMAOBCA1
SCHEMBL20004974 0.70 MIF (0.52) KDM4EMEN1KMT2ACYP3A4HPGD
SCHEMBL15676305 0.70 MAOA (0.67) KDM4EMEN1KMT2AMAOAMAOB
SCHEMBL24675929 0.69 MIF (0.47) KDM4EMEN1KMT2ACYP3A4HPGD
SCHEMBL897070 0.68 ALK (0.58)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230142119-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-05-11 US disclosed
US-20220306578-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2022-09-29 US disclosed
EP-3613729-A1 TETRACYCLIC COMPOUNDS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2020-02-26 EP disclosed
EP-3345903-B1 TETRACYCLIC COMPOUNDS CHUGAI PHARMACEUTICAL CO LTD (JP) 2019-10-09 EP disclosed
EP-3345903-A1 TETRACYCLIC COMPOUNDS Chugai Seiyaku Kabushiki Kaisha (JP) 2018-07-11 EP disclosed
EP-2975024-B1 TETRACYCLIC COMPOUNDS CHUGAI PHARMACEUTICAL CO LTD (JP) 2018-03-28 EP disclosed
US-20160340308-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-11-24 US disclosed
US-9440922-B2 Tetracyclic compound CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-09-13 US disclosed
EP-2441753-B1 TETRACYCLIC COMPOUND CHUGAI PHARMACEUTICAL CO LTD (JP) 2016-03-30 EP disclosed
EP-2975024-A1 TETRACYCLIC COMPOUNDS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-01-20 EP disclosed
US-9126931-B2 Tetracyclic compound CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-09-08 US disclosed
US-20150150845-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-06-04 US disclosed
EP-2441753-A1 TETRACYCLIC COMPOUND Chugai Seiyaku Kabushiki Kaisha (JP) 2012-04-18 EP disclosed
US-20120083488-A1 TETRACYCLIC COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA 2012-04-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230142119-A1 TETRACYCLIC COMPOUND ALK, TTR, ACVR1 KDM4E 903/4885MEN1 994/4885KMT2A 609/4885
US-20120083488-A1 TETRACYCLIC COMPOUND ALK, TTR, ACVR1 KDM4E 903/4885MEN1 994/4885KMT2A 609/4885
US-20220306578-A1 TETRACYCLIC COMPOUND ALK, TTR, ACVR1 KDM4E 903/4885MEN1 994/4885KMT2A 609/4885
US-20160340308-A1 TETRACYCLIC COMPOUND ALK, TTR, ACVR1 KDM4E 903/4885MEN1 994/4885KMT2A 609/4885
US-20150150845-A1 TETRACYCLIC COMPOUND ALK, TTR, ACVR1 KDM4E 903/4885MEN1 994/4885KMT2A 609/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.