Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15716659 | 0.92 | ALDH1A1 (0.67) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL8980650 | 0.86 | MAOB (0.54) | ALDH1A1TDP1L3MBTL1MAPK1MAOB | |
| SCHEMBL16789584 | 0.84 | ALDH1A1 (0.64) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL2640064 | 0.84 | ALDH1A1 (0.74) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL31354660 | 0.84 | ALDH1A1 (0.64) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL21022925 | 0.84 | ALDH1A1 (0.59) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL1317303 | 0.82 | POLB (0.59) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL4145578 | 0.82 | ALDH1A1 (0.58) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL4240186 | 0.82 | TDP1 (0.64) | ALDH1A1TDP1L3MBTL1TSHRCYP3A4 | |
| SCHEMBL8489879 | 0.82 | MAPT (0.57) | TDP1L3MBTL1MAPK1MAOBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1132508-A | Piperazine derivatives | REORDATI IND CHIMICA E FARMACE (CH) | 1996-10-02 | — | — | CN | disclosed |
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | disclosed |