Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39857 | 0.87 | ALDH1A1 (0.55) | APEX1ALDH1A1KDM4EHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL699717 | 0.85 | ALDH1A1 (0.53) | APEX1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL23108303 | 0.84 | KMT2A (0.47) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL9720578 | 0.84 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL3661643 | 0.82 | HPGD (0.54) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL4423235 | 0.82 | HMGCR (0.50) | ALDH1A1HPGDMAPTHMGCRHTT | |
| SCHEMBL1261117 | 0.81 | KMT2A (0.43) | APEX1ALDH1A1KDM4EHSD17B10MRGPRX4 | |
| SCHEMBL4597098 | 0.81 | HMGCR (0.41) | HMGCRNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27759786 | 0.81 | HPGD (0.52) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| SCHEMBL1648373 | 0.80 | MRGPRX4 (0.55) | APEX1ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1132508-A | Piperazine derivatives | REORDATI IND CHIMICA E FARMACE (CH) | 1996-10-02 | — | — | CN | claimed |
| JP-60064944-A | — | — | None | — | — | JP | disclosed |
| CN-1132508-A | Piperazine derivatives | REORDATI IND CHIMICA E FARMACE (CH) | 1996-10-02 | — | — | CN | disclosed |
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | disclosed |
| JP-S6064944-A | ACYLBENZOIC ACID DERIVATIVE AND PRODUCTION THEREOF | SANKYO KASEI KOGYO KK | 1985-04-13 | — | — | JP | disclosed |