Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.49 |
| ▸ | FABP4 | P15090 | 3/20 | 0.49 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8980620 | 0.85 | PLA2G1B (0.46) | ALDH1A1MEN1POLBKMT2AHTT | |
| SCHEMBL8980678 | 0.83 | TP53 (0.66) | ALDH1A1MEN1POLBKMT2AHTT | |
| SCHEMBL8980628 | 0.81 | ABCB1 (0.50) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8278415 | 0.80 | TP53 (0.61) | ALDH1A1MEN1POLBKMT2AHTT | |
| SCHEMBL1388155 | 0.79 | HTT (0.77) | ALDH1A1MEN1POLBKMT2AHTT | |
| SCHEMBL8980720 | 0.79 | ENPP2 (0.54) | ALDH1A1SGMS2KDM4ETRPM8MAOA | |
| SCHEMBL13690028 | 0.75 | TP53 (0.54) | ALDH1A1MEN1POLBKMT2AHTT | |
| Water SCHEMBL8980731 | 0.74 | KDM4E (0.47) | POLBHTTL3MBTL1KDM4E | |
| SCHEMBL27738026 | 0.74 | TSHR (0.44) | ALDH1A1KMT2AHTTTP53LMNA | |
| Water SCHEMBL8980780 | 0.73 | CAPN1 (0.49) | HTTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | disclosed |