Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8981075 | 0.97 | AGTR1 (0.37) | AGTR1AGTR2ALDH1A1GAAHPGD | |
| SCHEMBL8981364 | 0.89 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL8980824 | 0.88 | AGTR1 (0.47) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL8980963 | 0.87 | AGTR1 (0.44) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL8980694 | 0.87 | AGTR1 (0.35) | AGTR1AGTR2 | |
| SCHEMBL9667133 | 0.87 | AGTR1 (0.35) | AGTR1AGTR2 | |
| SCHEMBL8980604 | 0.87 | AGTR1 (0.38) | AGTR1AGTR2ALDH1A1GAAHPGD | |
| SCHEMBL8980696 | 0.86 | AGTR1 (0.34) | AGTR1AGTR2 | |
| SCHEMBL8980873 | 0.86 | AGTR1 (0.35) | AGTR1AGTR2 | |
| SCHEMBL8980960 | 0.86 | AGTR1 (0.34) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484937-A | ANGIOTENSIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1996-01-16 | — | — | US | disclosed |
| US-5175180-A | Antagonist, antagonism | G. D. SEARLE & CO. (US) | 1992-12-29 | — | — | US | disclosed |
| WO-1992011255-A1 | N-SUBSTITUTED N-(α-TRIAZOLYL-TOLUYL)PYRROLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-07-09 | — | — | WO | disclosed |